| Bioactivity | Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects[1][2][3]. | ||||||||||||
| Invitro | Chicoric acid (Cichoric acid; 10-200 μM; for 24, 48, and 72 h) causes a dose- and time-dependent decrease in cell viability[1]. Chicoric acid (100 μM; 48 h) induces apoptosis through caspase-3-dependent pathway[1]. Chicoric acid (100 μM; 48 h) decreases the protein level of p-Akt[1]. Chicoric acid (25, 50, 100 µM; for 24 hours) dramatically improves glucose uptake in a dose-dependent manner, and Chicoric acid further enhances insulin-induced (100 nM; 30 min) glucose uptake by 57.7% in HepG2 cells[2]. Chicoric acid (100 µM; for 24 hours) restores glucosamine-induced impairment of GLUT2 translocation through activating PI3K/Akt pathway in HepG2 cells[2]. Chicoric acid (100 µM) has no effects on HepG2 cell viability[2]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | Chicoric acid | ||||||||||||
| CAS | 6537-80-0 | ||||||||||||
| Formula | C22H18O12 | ||||||||||||
| Molar Mass | 474.37 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Chicoric acid
CAS: 6537-80-0 F: C22H18O12 W: 474.37
Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation
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