| Bioactivity | Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid has good coordination ability with noble metal ions. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM. | ||||||||||||
| Target | Ki: 33 μM (Glutamate decarboxylase). | ||||||||||||
| Invitro | Chelidamic acid is a heterocyclic organic acid with a pyran skeleton[1]. Chelidamic acid has good coordination ability with noble metal ions[2]. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM[3]. | ||||||||||||
| Name | Chelidamic acid | ||||||||||||
| CAS | 138-60-3 | ||||||||||||
| Formula | C7H5NO5 | ||||||||||||
| Molar Mass | 183.12 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Searcey M, et al. Synthesis, DNA-cleaving properties and cytotoxicity of intercalating chelidamic acid derivatives. Anticancer Drug Des. 13(8):837-55. [2]. Espinet P, et al. Mesogenic palladium complexes with pincer ligands derived from dipicolinic acid. Inorg Chem. 2000 Aug, 7;39(16):3645-51. [3]. Porter TG, et al. Chelidonic acid and other conformationally restricted substrate analogues as inhibitors of rat brain glutamate decarboxylase. Biochem Pharmacol. 1985 Dec 1;34(23):4145-50. |
Chelidamic acid
CAS: 138-60-3 F: C7H5NO5 W: 183.12
Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid has good coordination ability with
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