| Bioactivity | Ceapin-A7 is a selective blocker of ATF6α signaling in response to ER stress, with an IC50 of 0.59 μM. Ceapin-A7 can be used to explore both the mechanism of activation of ATF6α and its role in pathological settings[1]. | |||||||||
| Target | 0.59 μM (ATF6α) | |||||||||
| Invitro | Ceapin-A7 sensitizes cells to ER stress[1].Ceapin (0.6-18.9 μM; 4.5 hours) selectively inhibits ATF6α but not ATF6β[1]. | |||||||||
| Name | Ceapin-A7 | |||||||||
| CAS | 2323027-38-7 | |||||||||
| Formula | C20H12F6N4O3 | |||||||||
| Molar Mass | 470.32 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Ciara M Gallagher, et al. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch. eLife. 2016; 5: e11878. |
Ceapin-A7
CAS: 2323027-38-7 F: C20H12F6N4O3 W: 470.32
Ceapin-A7 is a selective blocker of ATF6α signaling in response to ER stress, with an IC50 of 0.59 μM. Ceapin-A7 can b
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