| Bioactivity | Carbobenzoxyproline (L-Cbz-Proline) is an inhibitor of prolidase. Carbobenzoxyproline can be used for prolidase deficiency (PD) research[1]. | ||||||||||||
| Invitro | Carbobenzoxyproline (6 mM; 0-10 d; pH=6.0) causes mitochondrial depolarization and increases cellular death by 33% as reported for long-term culture of fibroblasts from prolidase deficiency (PD) patients[1].Carbobenzoxyproline (0, 1, 3, 6 mM; 1 min; pH=6.0) results fibroblasts prolidase (FBP) hydrolysis, shows linear competitive inhibition[1]. | ||||||||||||
| In Vivo | Carbobenzoxyproline (60 mg/kg; injection; once daily; 3 weeks) serves as in vivo inhibitor of erythrocytes prolidase in mice model[1]. Animal Model: | ||||||||||||
| Name | Carbobenzoxyproline | ||||||||||||
| CAS | 1148-11-4 | ||||||||||||
| Formula | C13H15NO4 | ||||||||||||
| Molar Mass | 249.26 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Lupi A, et al. N-benzyloxycarbonyl-L-proline: an in vitro and in vivo inhibitor of prolidase. Biochim Biophys Acta. 2005 Jun 30;1744(2):157-63. |
Carbobenzoxyproline
CAS: 1148-11-4 F: C13H15NO4 W: 249.26
Carbobenzoxyproline (L-Cbz-Proline) is an inhibitor of prolidase. Carbobenzoxyproline can be used for prolidase deficien
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.