| Bioactivity | CSP1 is a potent and selective ComD1 receptor agonist, with an IC50 of 10.3 nM. CSP1 is a major variants of competence-stimulating peptide (CSP), and it can regulate genetic transformation of S. pneumonia by modulating quorum sensing (QS). CSP1 can act as an antibacterial agent[1][2]. | ||||||
| Target | IC50: 10.3 nM (ComD1 receptor) | ||||||
| Name | CSP1 | ||||||
| CAS | 172889-49-5 | ||||||
| Shortening | EMRLSKFFRDFILQRKK | ||||||
| Formula | C103H168N30O24S | ||||||
| Molar Mass | 2242.69 | ||||||
| Appearance | Solid | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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| Reference | [1]. Yang Y, et, al. Structural Characterization of Competence-Stimulating Peptide Analogues Reveals Key Features for ComD1 and ComD2 Receptor Binding in Streptococcus pneumonia. Biochemistry. 2018 Sep 11;57(36):5359-5369. [2]. Johnsborg O, et, al. A hydrophobic patch in the competence-stimulating Peptide, a pneumococcal competence pheromone, is essential for specificity and biological activity. J Bacteriol. 2006 Mar; 188(5): 1744-9. |
CSP1
CAS: 172889-49-5 F: C103H168N30O24S W: 2242.69
CSP1 is a potent and selective ComD1 receptor agonist, with an IC50 of 10.3 nM. CSP1 is a major variants of competence-s
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