| Bioactivity | CN128 hydrochloride (CN328) is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia[1]. |
| Invitro | CN128 hydrochloride possesses a high selectivity for iron(III) over others metals[1]. |
| In Vivo | CN128 hydrochloride (450 μmol/kg; p.o.) exhibits a good iron scavenging efficacy in rat[1].The iron removal efficacies of CN128 displays a dose-dependent behavior[1].CN128 hydrochloride lacks genetic toxicity[1].CN128 hydrochloride (75 μmol/kg; i.g.) possesses good oral bioavailability (82.6%), high maximal plasma concentration, and low clearance rats after an oral dose of 75 μmol/kg[1].CN128 hydrochloride is well-tolerated, with no mortality being observed at the higher dose levels in rats[1]. Animal Model: |
| Name | CN128 hydrochloride |
| CAS | 1335282-05-7 |
| Formula | C15H18ClNO3 |
| Molar Mass | 295.76 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Wenteng Chen, et al. CN128: A New Orally Active Hydroxypyridinone Iron Chelator. J Med Chem. 2020 Apr 23;63(8):4215-4226. |
CN128 hydrochloride
CAS: 1335282-05-7 F: C15H18ClNO3 W: 295.76
CN128 hydrochloride (CN328) is an orally active and selective iron chelator. CN128 is used for the research of β-thalas
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