| Bioactivity | CD31 (PECAM-1) TFA is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 TFA is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 TFA peptide is able to sustain phosphorylation of the CD31 ITIM686 and of SHP2 and to inhibit TCR-induced T-cell activation[1]-[5]. |
| Invitro | CD31 TFA is a trans-homophilic co-signaling protein at the crossroad between mechanical stress, metabolism and inflammation[1].CD31 TFA is a ER-MP12 antigen, exerts function as promoting cell adhesion between endothelial cells, enabling transmigration of leukocytes across vascular endothelium, and producing signaling to up-regulation of other adhesion molecules in neighboring cells[2].Clostridium perfringens b-toxin (CPB) is a highly active b-pore-forming toxin (b-PFT) and the essential virulence factor for fatal, necro-hemorrhagic enteritis[3].CD31 TFA serves as the specific membrane receptor for clostridium perfringens b-toxin (CPB) on endothelial cells. CD31 TFA directly interacts with CPB, with the membrane proximal Ig6 domain[3].CD31 TFA also serves as a therapeutic target in atherosclerosis[4].CD31 TFA (0, 25, 50, 100 μg/mL) induces proliferative response to TCR engagement of human PBMCs in a dose-dependent manner[5]. |
| Name | CD31 TFA |
| Shortening | NHASSVPRSKILTVRVILAPWKK |
| Formula | C121H203F3N36O31 |
| Molar Mass | 2715.12 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |