| Bioactivity | C-176 is a strong and covalent mouse STING inhibitor[1]. | ||||||||||||
| Target | STING. | ||||||||||||
| Invitro | C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6[1]. | ||||||||||||
| In Vivo | C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity[1].C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1−/− mice[1].C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1−/− mice[1]. Animal Model: | ||||||||||||
| Name | C-176 | ||||||||||||
| CAS | 314054-00-7 | ||||||||||||
| Formula | C11H7IN2O4 | ||||||||||||
| Molar Mass | 358.09 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273. |