Butyzamide_product_DataBase

Bioactivity	Butyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay[1].
Invitro	Butyzamide (3 μM；15 分钟) 诱导 Ba/F3-hMpl 细胞中 JAK2、STAT3、STAT5 和 MAPK 的磷酸化[1]。Butyzamide (3 μM; 48 小时) 诱导人 CD34+ 造血祖细胞产生集落形成单位-巨核细胞和多倍体巨核细胞[1]。
In Vivo	Butyzamide (10 mg/kg、50 mg/kg；口服；每天一次，持续 20 天) 在移植了人胎肝来源的 CD34+ 细胞的 NOG 小鼠内增加人血小板水平[1]。
Name	Butyzamide
CAS	1110767-45-7
Formula	C29H32Cl2N2O5S
Molar Mass	591.55
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Nogami W, et al. The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis. Haematologica. 2008 Oct;93(10):1495-504.

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