| Bioactivity | Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM). Butyrolactone 3 can be used in studies of cancer, metabolic, autoimmune and neurological diseases[1][2]. | |||
| Name | Butyrolactone 3 | |||
| CAS | 778649-18-6 | |||
| Formula | C9H12O4 | |||
| Molar Mass | 184.19 | |||
| Appearance | Solid | |||
| Transport | Room temperature in continental US; may vary elsewhere. | |||
| Storage |
*该产品在溶液状态不稳定，建议您现用现配，即刻使用。 |
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| Reference | [1]. Biel M,et al. Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5.Angew Chem Int Ed Engl. 2004 Jul 26;43(30):3974-6 [2]. Haque ME, et al. The GCN5: its biological functions and therapeutic potentials. Clin Sci (Lond). 2021 Jan 15;135(1):231-257. |
Butyrolactone 3
CAS: 778649-18-6 F: C9H12O4 W: 184.19
Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), wh
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