| Bioactivity | Butamben (Butyl 4-aminobenzoate) results in long-lasting relief from pain, without impairing motor function or other sensory functions[1][2]. | ||||||||||||
| Target | Calcium ChannelSodium Channel | ||||||||||||
| Invitro | Butamben (500 μM) blocks 90% of the control barium current, and this level is reached within 4 min in PC12 cells[2].Butamben (100 μM; 2-10 min) increases the inactivation of the fast Na+ channels, but not of the slow Na+ channels[3]. | ||||||||||||
| In Vivo | Butamben (0.5-50 mM; the distal portion of the tail was immersed for 2 min) has an S-shape dose-dependent analgesic activity in the radiant heat tail-flick assay of mice[4]. | ||||||||||||
| Name | Butamben | ||||||||||||
| CAS | 94-25-7 | ||||||||||||
| Formula | C11H15NO2 | ||||||||||||
| Molar Mass | 193.24 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Cereda CM, et al. Liposomal butamben gel formulations: toxicity assays and topical anesthesia in an animal model. J Liposome Res. 2017 Mar;27(1):74-82. [2]. Rampaart LJA, et, al. The local anesthetic butamben inhibits total and L-type barium currents in PC12 cells. Anesth Analg. 2008 Jun;106(6):1778-83. [3]. Berg RJV, et, al. The local anesthetic n-butyl-p-aminobenzoate selectively affects inactivation of fast sodium currents in cultured rat sensory neurons. Anesthesiology. 1995 Jun;82(6):1463-73. [4]. Kolesnikov YA, et, al. Analgesic synergy between topical morphine and butamben in mice. Anesth Analg. 2003 Oct;97(4):1103-7, table of contents. |