| Bioactivity | Buloxibutid (AT2 receptor agonist C21) is a druglike selective angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and >10 μM for the AT2 receptor and AT1 receptor, respectively[1]. | ||||||||||||
| In Vivo | Buloxibutid, with a bioavailability of 20-30% after oral administration and a half-life estimated to 4 h in rat, induces outgrowth of neurite cells, stimulates p42/p44mapk, enhances in vivo duodenal alkaline secretion in Sprague-Dawley rats, and lowers the mean arterial blood pressure in anesthetized, spontaneously hypertensive rats[1]. | ||||||||||||
| Name | Buloxibutid | ||||||||||||
| CAS | 477775-14-7 | ||||||||||||
| Formula | C23H29N3O4S2 | ||||||||||||
| Molar Mass | 475.62 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Wan Y, et al. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem. 2004 Nov 18;47(24):5995-6008. [2]. Schwengel K, Namsolleck P, Lucht K, et al. Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice. J Mol Med (Berl). 2016;94(8):957-966. [3]. Fatima N, Patel S, Hussain T. Angiotensin AT2 Receptor is Anti-inflammatory and Reno-Protective in Lipopolysaccharide Mice Model: Role of IL-10. Front Pharmacol. 2021;12:600163. |
Buloxibutid
CAS: 477775-14-7 F: C23H29N3O4S2 W: 475.62
Buloxibutid (AT2 receptor agonist C21) is a druglike selective angiotensin II AT2 receptor agonist with Ki values of 0.4
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