| Bioactivity | Betazole (Ametazole) dihydrochloride, a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazole dihydrochloride induces gastric acid secretion, and causes an immediate and significant increase in common bile duct pressure. Betazole dihydrochloride has been used as a diagnostic agent known as histalog, for investigating gastric acid secretory capacity[1][2][3]. |
| Invitro | Betazole (Ametazole) dihydrochloride is a weak histamine agonist with relative selectivity towards H2 receptors and only minimal H1 activity. Betazole dihydrochloride induces gastric inhibitory polypeptide (GIP) secretion[1]. |
| Name | Betazole dihydrochloride |
| CAS | 138-92-1 |
| Formula | C5H11Cl2N3 |
| Molar Mass | 184.07 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Maples MD, Effects of betazole hydrochloride and cimetidine on common bile pressure and duodenal myoelectric activity in the dog. Am Surg. 1981;47(12):519-521. [2]. Spitz IM, Betazole-induced GIP secretion is not mediated by gastric HCl. Metabolism. 1982;31(4):380-382. [3]. CLAYMAN CB,. A simple oral gastric secretory stimulant (betazole hydrochloride). JAMA. 1961;175:908-909. |
Betazole dihydrochloride
CAS: 138-92-1 F: C5H11Cl2N3 W: 184.07
Betazole (Ametazole) dihydrochloride, a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazol
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