| Bioactivity | Berberine hemisulfate is the hemisulfate form of Berberine (HY-N0716). Berberine hemisulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian. Berberine hemisulfate exhibits anti-inflammatory, antibiobic, antitumor, cardiovascular protective and neuroprotective activity[1][2][3][4][5][6]. |
| Invitro | Berberine hemisulfate 通过抑制细胞分裂蛋白 (FtsZ) 或通过结合 DNA/RNA 并造成 DNA/RNA 损伤，发挥抗菌活性[3]。Berberine hemisulfate 通过抑制 TNF-α 及其下游通路 AP-1 和 NF-kB 的激活，发挥抗炎活性[4]。 Berberine hemisulfate 通过抑制活性氧 (ROS) 的产生和 caspase 激活，激活 PI3K/Akt 信号通路和上调血红素加氧酶-1 (HO-1) 表达，发挥神经保护活性[5]。Berberine hemisulfate 通过调节脂质和抑制胰岛素抵抗来改善代谢疾病[6]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Berberine hemisulfate 相关抗体: |
| CAS | 316-41-6 |
| Formula | C20H18NO4.1/2O4S |
| Molar Mass | 384.40 |
| Appearance | 固体 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Cai Y, et al. Berberine inhibits the growth of human colorectal adenocarcinoma in vitro and in vivo. J Nat Med. 2014 Jan;68(1):53-62. [2]. Cui HX, et al. Preparation and Evaluation of Antidiabetic Agents of Berberine Organic Acid Salts for Enhancing the Bioavailability. Molecules. 2018 Dec 28;24(1):103. [3]. Boberek JM, et al., Genetic evidence for inhibition of bacterial division protein FtsZ by berberine. PLoS One. 2010 Oct 29;5(10):e13745. [4]. Remppis A, et al., Rhizoma Coptidis inhibits LPS-induced MCP-1/CCL2 production in murine macrophages via an AP-1 and NFkappaB-dependent pathway. Mediators Inflamm. 2010;2010:194896. [5]. Bae J, et al., Berberine protects 6-hydroxydopamine-induced human dopaminergic neuronal cell death through the induction of heme oxygenase-1. Mol Cells. 2013 Feb;35(2):151-7. [6]. Ye Y, et al., Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Front Pharmacol. 2021 Apr 26;12:653887. |
Berberine hemisulfate
CAS: 316-41-6 F: C20H18NO4.1/2O4S W: 384.40
Berberine hemisulfate is the hemisulfate form of Berberine (HY-N0716). Berberine hemisulfate is an alkaloid isolated fro
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