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Benzosceptrin C

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Bioactivity Benzosceptrin C is an inhibitor for PD-L1, which promotes programmed cell death ligand (PD-L1) degradation in a lysosomal pathway, enhances the cytotoxicity of T-cells and exhibits antitumor activity[1].
Invitro Benzosceptrin C (0-10 μM) 抑制 CRC 癌细胞中的 PD-L1 表达，通过破坏 PD-L1 检查点增强 T 细胞的细胞毒性，并抑制 CRC 癌细胞 RKO 和 HCT116 的增殖[1]。Benzosceptrin C (0-10 μM) 通过抑制 DHHC3 的活性阻断 PD-L1 的棕榈酰化，从而促进 PD-L1 的溶酶体降解，阻断 PD-L1 与 PD-1 的直接相互作用，发挥免疫抗肿瘤作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Benzosceptrin C 相关抗体: Cell Proliferation Assay[1] Cell Line:
In Vivo Benzosceptrin C (5-50 mg/kg/day，腹腔注射，16 天) 通过激活肿瘤浸润 T 细胞和诱导细胞凋亡 (apoptosis) 抑制 MC38 异种移植 C57BL/6 小鼠的肿瘤生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS 1204605-36-6
Formula C22H18Br4N10O2
Molar Mass 774.06
Transport Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Reference [1]. Wang Q, et al., Benzosceptrin C induces lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting DHHC3. Cell Rep Med. 2024 Feb 20;5(2):101357.
How to place a order： 1) Contact us at: Whatsapp:+86-(0)-18753388868 or peptidedb@qq.com;
2) Provide us peptides information including Sequence, Purity, Quantity and modification(If necessary, we agree to sign confidential agreement with you before you provide these information), we will make you a quotes within 30 minutes;
3) Place us a purchaser order, we can send you a sales contract too if you need;
4) Start synthesis, and we will inform you the updates of synthesis in time;
5) Arrange shippment, HPLC analysis, MS spectrum will be shipped along the peptides too;
6) Refund all pre-payment(if pre-pay us) if we failed to synthesize any of them;
7) After-sale service: Contact us anytime if you have any problem when you use the peptides, and we will reply you as soon as possible.
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