| Bioactivity | BT44 is a selective RET activator. BT44 can penetrate through the blood-brain barrier and can be used for the research of neurodegenerative disorders and diabetes mellitus[1][2]. | ||||||||||||
| Invitro | BT44 (7.5-75 μM; 15 min) 促进 RET 磷酸化并选择性激活表达 GFL 受体的细胞的下游级联反应[1]。BT44 (0.5-10 μM; 16-20 h) 促进感觉神经元的神经突生长[1]。 Western Blot Analysis[1] Cell Line: | ||||||||||||
| In Vivo | BT44 (5-25 mg/kg; s.c.; every second day for 10, 42 or 14 days) 在神经性的 SNL 和 STZ 模型中可减轻感觉体征[1]。BT44 (12.5 or 25 mg/kg; s.c.; every second day for 10 days) 对实验性神经病变动物 DRGs 中 IB4 阳性神经元有保护作用[1]。BT44 (0.1 and 0.3 μg/24 h; infuse into the right dorsal striatum for 14 days) 在 6-OHDA 帕金森大鼠模型中逆转 amphetamine 引起的运动失衡，似乎保护纹状体中的多巴胺能纤维[2]。BT44 (10 mg/kg; i.v.) 穿过血脑屏障，在大鼠中迅速从循环 (半衰期 (t1/2) = 0.72 h) 和脑 (t1/2 = 0.47 h) 中消除[2]。 Animal Model: | ||||||||||||
| Name | BT44 | ||||||||||||
| CAS | 924759-42-2 | ||||||||||||
| Formula | C28H27F4N3O4S | ||||||||||||
| Molar Mass | 577.59 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Viisanen H, et al. Novel RET agonist for the treatment of experimental neuropathies. Mol Pain. 2020 Jan-Dec;16:1744806920950866. [2]. Renko JM, et al. Neuroprotective Potential of a Small Molecule RET Agonist in Cultured Dopamine Neurons and Hemiparkinsonian Rats. J Parkinsons Dis. 2021;11(3):1023-1046. |