| Bioactivity | BPK-21, an active acrylamide, suppresses T cell activation through blockade of ERCC3 function. BPK-21 specifically targets C342 in the helicase ERCC3[1]. | ||||||||||||
| Invitro | BPK-21 (20 μM) significantly impairs T cellactivation[1]. BPK-21 likely suppresses T cell activation through blockadeof ERCC3 function, which may in turn act downstream or sepa-rately from pathways involved in NFAT and NF-kB activation[1]. | ||||||||||||
| Name | BPK-21 | ||||||||||||
| CAS | 2305052-77-9 | ||||||||||||
| Formula | C23H16Cl2F3NO2 | ||||||||||||
| Molar Mass | 466.28 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Ekaterina V Vinogradova, et al. An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. |
BPK-21
CAS: 2305052-77-9 F: C23H16Cl2F3NO2 W: 466.28
BPK-21, an active acrylamide, suppresses T cell activation through blockade of ERCC3 function. BPK-21 specifically targe
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