BMS-433771 dihydrochloride hydrate_product_DataBase

Bioactivity	BMS-433771 dihydrochloride hydrate is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 dihydrochloride hydrate is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 dihydrochloride hydrate can be used for the research of respiratory tract disease[1][2].
Target	EC50: 20 nM (RSV)
Invitro	BMS-433771 dihydrochloride hydrate 对 A 组和 B 组 RSV 均具有抑制作用，平均 EC50 为 20 nM[1]。BMS-433771 dihydrochloride hydrate 可抑制病毒 F 蛋白诱导的膜融合[1]。
In Vivo	BMS-433771 dihydrochloride hydrate (口服；1-200 mg/kg；每天 1 或 2 次，共 4 天) 通过口服给药显示出预防效果，但两种啮齿动物模型之间具有相当大的药效学差异[2] .
Name	BMS-433771 dihydrochloride hydrate
CAS	543700-67-0
Formula	C21H27Cl2N5O3
Molar Mass	468.38
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Christopher Cianci, et al. Antiviral activity and molecular mechanism of an orally active respiratory syncytial virus fusion inhibitor. J Antimicrob Chemother [2]. Christopher Cianci, et al. Oral efficacy of a respiratory syncytial virus inhibitor in rodent models of infection. Antimicrob Agents Chemother. 2004 Jul;48(7):2448-54.

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