BMS-191011_product_DataBase

Bioactivity

BMS 191011 (BMS-A) is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel). BMS-191011 shows neuroprotective activities in rodent models of stroke[1].

Invitro

BMS-191011 (20 or 40 µM) activates BK channels in IGR39 cells, and leads to potentiation in Panc-1 cells[3]. Cell Viability Assay[3] Cell Line:

In Vivo

BMS-191011 (intravenous injection; 10-100 µg/kg; once) dilates rat retinal arterioles through activation of iberiotoxin-sensitive BK(Ca) channels in vivo[2]. Animal Model:

Name

BMS-191011

CAS

202821-81-6

Formula

C16H10ClF3N2O3

Molar Mass

370.71

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Romine JL, et al. 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR. J Med Chem. 2007 Fe [2]. Asami Mori, et al. BMS-191011, an opener of large-conductance Ca2+-activated potassium channels, dilates rat retinal arterioles in vivo. Biol Pharm Bull. 2011;34(1):150-2. [3]. Remigante A, et al. NS-11021 Modulates Cancer-Associated Processes Independently of BK Channels in Melanoma and Pancreatic Duct Adenocarcinoma Cell Lines. Cancers (Basel). 2021 Dec 6;13(23):6144.

PeptideDB

BMS-191011

CAS: 202821-81-6 F: C16H10ClF3N2O3 W: 370.71