| Bioactivity | BML-210 is a potent HDAC inhibitor. BML-210 can inhibit the HDAC4-VP16-driven reporter signal with an apparent IC50 of ∼5 µM. BML-210 has a specific disruptive effect on the HDAC4:MEF2 interaction. BML-210 causes an increase in the G0/G1 phase. BML-210 induces apoptosis and displays antitumour activities in orthotopic mammary tumours in mice[1][2][3]. | ||||||||||||
| Invitro | BML-210 (10, 20 μM; 24, 48小时) 抑制 NB4 细胞的增殖和生长[2]。BML-210 (10, 20 μM; 24, 48小时) 导致 NB4 细胞在 S 期的比例降低，G0/G1 期的比例增加[2]。BML-210 (10, 20 μM; 24, 48小时) 在 20μM 时对NB4细胞产生细胞毒性作用。BML-210 以 10μM 剂量可以诱导凋亡细胞死亡[2]。BML-210 (10, 20 μM; 24, 48小时) 抑制 NB4 细胞中 HDAC 的表达和活性[2]。BML-210 不降低 HDAC4-VP16 的表达[1]。 Cell Proliferation Assay[2] Cell Line: | ||||||||||||
| Name | BML-210 | ||||||||||||
| CAS | 537034-17-6 | ||||||||||||
| Formula | C20H25N3O2 | ||||||||||||
| Molar Mass | 339.43 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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