| Bioactivity | BLM-IN-2 is a Bloom's Syndrome Protein (BLM) inhibitor with an IC50 value of 0.8 μM. BLM-IN-2 effectively suppresses the proliferation, invasion, cell cycle arrest and apoptosis of CRC cells. BLM-IN-2 can be used for the reserarch of colorectal cancer (CRC)[1]. |
| Target | IC50: 0.8 μM (BLM) |
| Invitro | BLM-IN-2 (0-20 μM) 对 BLM 有良好的抑制作用，解旋和结合 DNA 的 IC50 值分别为 0.8 μM 和 2.3 μM[1]。BLM-IN-2 对 CRC 细胞表现出强大的 BLM 依赖性细胞毒性，但对正常细胞表现出弱毒性[1]。BLM-IN-2（3 μM；48 h）破坏 HRR 水平，同时抑制位于 DSB 位点的 BLM，并触发 CRC 细胞中的 DNA 损伤[1]。BLM-IN-2 (0-5 μM; 48 h) 有效抑制 CRC 细胞的增殖和侵袭，以及细胞周期停滞和细胞凋亡[1]。 Cell Proliferation Assay[1] Cell Line: |
| Name | BLM-IN-2 |
| Formula | C33H38BrFN4O |
| Molar Mass | 605.58 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jia-Li Tu, et al. Design, synthesis and evaluation of N3-substituted quinazolinone derivatives as potential Bloom's Syndrome protein (BLM) helicase inhibitor for sensitization treatment of colorectal cancer. Eur J Med Chem. 2022 Nov 21;246:114944. |