Bioactivity | Azenosertib (ZN-c3) is a selective, orally active inhibitor for Wee1 inhibitor (IC50=3.9 nM). Azenosertib exhibits antitumor activity[1]. | ||||||||||||
Target | IC50: 3.9 nM (Wee1) | ||||||||||||
Invitro | Azenosertib 抑制癌细胞 H23 和 A427 的增殖,IC50 为 103 和 75 nM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Azenosertib 相关抗体: Cell Proliferation Assay[1] Cell Line: | ||||||||||||
In Vivo | Azenosertib (80 mg/kg,口服 28 天) 抑制 A427 异种移植肿瘤在 NOD/SCID 小鼠模型中的肿瘤生长[1]。Azenosertib (10 mg/kg,口服) 的药代动力学数据表明,Azenosertib 在比格犬模型中的血浆暴露率是Cmax = 2.1 μM,半衰期 T1/2 为 2.3 h,AUC0-24 h 为 9.7 μM·h,口服利用率为 F=142%[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: | ||||||||||||
CAS | 2376146-48-2 | ||||||||||||
Formula | C29H34N8O2 | ||||||||||||
Molar Mass | 526.63 | ||||||||||||
Appearance | 固体 | ||||||||||||
Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
Storage |
|
||||||||||||
Reference | [1]. Huang PQ, et al. Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer [published online ahead of print, 2021 Aug 23]. J Med Chem. 2021;10.1021/acs.jmedchem.1c01121. |