| Bioactivity | Azacyclonol (γ-pipradol), a metabolite of Terfenadine, is a central depressant agent. Azacyclonol is a ganglion-blocking agent. Azacyclonol can be used to diminish psychoses-induced hallucinations[1][2][3]. | ||||||||||||
| Invitro | Azacyclonol is formed from Terfenadine in rat liver[2]. | ||||||||||||
| In Vivo | Azacyclonol causes depressed activity in mice and rats[3].Azacyclonol antagonizes increased coordination activity in mice induced by pipradrol, amphetamine, morphine and cocaine and prolongs Hexobarbital hypnosis[3]. | ||||||||||||
| Name | Azacyclonol | ||||||||||||
| CAS | 115-46-8 | ||||||||||||
| Formula | C18H21NO | ||||||||||||
| Molar Mass | 267.37 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Brown DA, et, al. The effects of some centrally acting drugs on ganglionic transmission in the cat. [2]. Jurima-Romet M, et, al. Induction of CYP3A and associated terfenadine N-dealkylation in rat hepatocytes cocultured with 3T3 cells. Cell Biol Toxicol. 1995 Dec;11(6):313-27. [3]. BRAUN DL, et, al. The pharmacologic activity of alpha-(4-piperidyl)-benzhydrol hydrochloride (azacyclonol hydrochloride); an ataractive agent. J Pharmacol Exp Ther. 1956 Oct;118(2):153-61. |