| Bioactivity | Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate can be used for research of anti-myopia and bradycardia[1][2][3][4]. |
| Invitro | Atropine (Tropine tropate; 1 μM; pulmonary veins and arteries) sulfate inhibits ACh-induced relaxations in human pulmonary veins[4]. |
| In Vivo | Atropine (Tropine tropate; 10 mg/kg; i.p.; once, for 40 minutes; Peromyscus sp.) sulfate inhibits the cardiac arrhythmia which normally occurs throughout torpor[2]. Animal Model: |
| Name | Atropine sulfate |
| CAS | 55-48-1 |
| Formula | C17H24NO5S0.5 |
| Molar Mass | 338.41 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *该产品在溶液状态不稳定，建议您现用现配，即刻使用。 |
| Reference | [1]. McBrien NA, et, al. How does atropine exert its anti-myopia effects? Ophthalmic Physiol Opt. 2013 May;33(3):373-8. [2]. Morhardt JE. Heart rates, breathing rates and the effects of atropine and acetylcholine on white-footed mice (Peromyscus sp.) during daily torpor. Comp Biochem Physiol. 1970 Mar 15;33(2):441-57. [3]. Carr BJ, et, al. Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro. Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2778-2791. [4]. Walch L, et, al. Evidence for a M(1) muscarinic receptor on the endothelium of human pulmonary veins. Br J Pharmacol. 2000 May;130(1):73-8. |
Atropine sulfate
CAS: 55-48-1 F: C17H24NO5S0.5 W: 338.41
Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 value
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