| Bioactivity | Astaxanthin, the red dietary carotenoid, is an orally effective and potent antioxidant. Astaxanthin inhibits NF-κB and down-regulates VEGF in blood glucose. Astaxanthin exerts anti-cancer cell proliferation, increases apoptosis, impairs migration and invasion by activating PPARγ and reducing the expression of STAT3. Astaxanthin also has neuroprotective and anti-inflammatory activity and can be used in studies of cancer, diabetic retinopathy, cardiovascular disease, and in the coloring of animal feed[1][2][3][4][5]. |
| Invitro | Astaxanthin (50, 100, 150, 200 µM; 48 h) inhibits the proliferation of DU145 cells (IC50<200 µM)[1].Astaxanthin (200 µM; 24 h) reduces the expression of STAT3 and the related pathway proteins (at both protein and mRNA levels) by inhibiting proliferation, increasing apoptosis and weakening migration and invasion[1]Astaxanthin protects RPE cells from abnormal activation and oxidative stress (induced by high glucose) by down-regulating VEGF in high glucose at protein levels[2].Astaxanthin (1-50 µM; 72 h) upregulates protein expression of PPARγ in time- and dose-dependent manners in K562 cells[3]. Apoptosis Analysis[1] Cell Line: |
| Name | Astaxanthin |
| CAS | 472-61-7 |
| Formula | C40H52O4 |
| Molar Mass | 596.84 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, protect from light, stored under nitrogen *该产品在溶液状态不稳定，建议您现用现配，即刻使用。 |