| Bioactivity | Argininosuccinic acid participates in the fourth step of the urea cycle, with being cleaved to arginine and fumaric acid by argininosuccinic acid lyase (ASL). Argininosuccinic acid reduces reduced glutathione (GSH) level, and increases the production of reactive oxygen species in cerebral cortex and striatum. Argininosuccinic acid causes lipid peroxidation and protein oxidation, and induces oxidative stress in the developing rat brain[1][2]. |
| Invitro | Argininosuccinic acid (250-1000 μM; 1 h) 显著增加丙二醛水平，减少巯基和羰基的形成 (蛋白质氧化) 在大脑皮层[1]。Argininosuccinic acid (250-1000 μM; 1 h) 降低 30 日龄大鼠大脑皮层还原性谷胱甘肽 (GSH) 浓度[1]。Argininosuccinic acid (500 μM; 1 h) 增加了30 日龄大鼠大脑皮层的二氯荧光黄含量[1]。 |
| Name | Argininosuccinic acid |
| CAS | 2387-71-5 |
| Formula | C10H18N4O6 |
| Molar Mass | 290.27 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Argininosuccinic acid
CAS: 2387-71-5 F: C10H18N4O6 W: 290.27
Argininosuccinic acid participates in the fourth step of the urea cycle, with being cleaved to arginine and fumaric acid
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