| Bioactivity | Argininosuccinic acid disodium participates in the fourth step of the urea cycle and is cleaved into arginine and fumarate by argininosuccinate lyase (ASL). Argininosuccinic acid disodium reduces reduced glutathione (GSH) concentrations and increases reactive oxygen species production in the cerebral cortex and striatum. Argininosuccinic acid disodium causes lipid peroxidation and protein oxidation and also induces oxidative stress in the developing rat brain[1][2]. |
| Name | Argininosuccinic acid disodium |
| CAS | 918149-29-8 |
| Formula | C10H16N4Na2O6 |
| Molar Mass | 334.24 |
| Appearance | 固体 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Seminotti B, et al. Free Radical Scavengers Prevent Argininosuccinic Acid-Induced Oxidative Stress in the Brain of Developing Rats: a New Adjuvant Therapy for Argininosuccinate Lyase Deficiency? Mol Neurobiol. 2020 Feb;57(2):1233-1244. [2]. Nagamani SCS, et al. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2023. |
Argininosuccinic acid disodium
CAS: 918149-29-8 F: C10H16N4Na2O6 W: 334.24
Argininosuccinic acid disodium participates in the fourth step of the urea cycle and is cleaved into arginine and fumara
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