| Bioactivity | Arachidonoyl Serinol, an endogenous cannabimimetic metabolite, is an inhibitor of monoacylglycerol lipase (MAGL). Arachidonoyl Serinol inhibits the hydrolysis of [3H]2-oleoylglycerol and [3H]anandamide with IC50s of ∼70 μM[1][2][3]. |
| Target | monoacylglycerol lipase (MAGL) |
| Invitro | Arachidonoyl Serinol (0.2-100 μM) inhibits the hydrolysis of [3H]2-oleoylglycerol and [3H]anandamide with IC50s of ∼70 μM[2]. |
| Name | Arachidonoyl Serinol |
| CAS | 183718-70-9 |
| Formula | C23H39NO3 |
| Molar Mass | 377.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Khanolkar AD, et, al. Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand. J Med Chem. 1996 Oct 25;39(22):4515-9. [2]. Fowler CJ, et, al. Cyclooxygenation of the arachidonoyl side chain of 1-arachidonoylglycerol and related compounds block their ability to prevent anandamide and 2-oleoylglycerol metabolism by rat brain in vitro. Biochem Pharmacol. 2005 Apr 15;69(8):1241-5 [3]. Ghafouri N, et, al. Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. Br J Pharmacol. 2004 Nov;143(6):774-84. |
Arachidonoyl Serinol
CAS: 183718-70-9 F: C23H39NO3 W: 377.56
Arachidonoyl Serinol, an endogenous cannabimimetic metabolite, is an inhibitor of monoacylglycerol lipase (MAGL). Arachi
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