| Bioactivity | Apyramide is an anti-inflammatory agent (NSAID) and behaves as a prodrug of indomethacin (HY-14397)[1]. Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2. | ||||||||||||
| In Vivo | Apyramide is far less toxic than indomethacin in rats and mice by the oral or the i.p. route. It exhibits anti-inflammatory activity on carrageenin-induced paw oedema, cotton pellet granuloma and adjuvant arthritis, as well as analgesic and antipyretic activities[1]. | ||||||||||||
| Name | Apyramide | ||||||||||||
| CAS | 68483-33-0 | ||||||||||||
| Formula | C27H23ClN2O5 | ||||||||||||
| Molar Mass | 490.93 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Sauvaire D, et al. Pharmacological activity and toxicity of apyramide: comparison with non-steroidal anti-inflammatory agents. Drugs Exp Clin Res. 1987;13(5):247-52. [2]. M Cociglio, et al. Pharmacokinetics of an indomethacin pro-drug: apyramide after intravenous administration in dog. Eur J Drug Metab Pharmacokinet. Oct-Dec 1991;16(4):275-80. |