Apoptosis inducer 7_product_DataBase

Bioactivity	Apoptosis inducer 7 (Compound 5I) induces apoptosis in cancer cells. Apoptosis inducer 7 inducrs cleavage of PARP, caspases, down-regulation of anti-apoptotic protein c-Flip and up regulation of pro-apoptotic protein Noxa. Apoptosis inducer 7 exhibits antitumor activity[1].
Invitro	Apoptosis inducer 7 (Compound 5I) (0.098-50 μM, 96 hours; human tumor cell lines) exerts the most potent antitumor activities against human cancer cell lines[1].Apoptosis inducer 7 (Compound 5I) induces apoptosis in HCT-116 cells, and the apoptosis induction is related to the downregulation of anti-apoptotic protein c-Flip and upregulation of pro-apoptotic protein Noxa[1]. Cell Cytotoxicity Assay[1] Cell Line:
In Vivo	Apoptosis inducer 7 (Compound 5I) (5 mg/kg; i.p.; three times a week, for 14 days; LL/2 xenograft model in C57/ BL6J mice) inhibits tumor growth[1]. Animal Model:
Name	Apoptosis inducer 7
CAS	2252278-57-0
Formula	C49H68N2O7
Molar Mass	797.07
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Huang M, et al. Synthesis and antitumor effects of novel 18β-glycyrrhetinic acid derivatives featuring an exocyclic α,β-unsaturated carbonyl moiety in ring A. Bioorg Chem. 2020 Oct;103:104187.

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