| Bioactivity | Api137 is an antimicrobial peptide that interferes with bacterial growth by inhibiting translation. Api137 inhibit protein synthesis by trapping of release factors on the 70S ribosome following hydrolysis of the nascent polypeptide chain[1][2]. |
| Name | Api137 |
| Sequence | {TMG}-{Orn}-Asn-Asn-Arg-Pro-Val-Tyr-Ile-Pro-Arg-Pro-Arg-Pro-Pro-His-Pro-Arg-Leu |
| Shortening | {TMG}-{Orn}-NNRPVYIPRPRPPHPRL |
| Formula | C104H171N37O22 |
| Molar Mass | 2291.71 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Florin T, et, al. An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome. Nat Struct Mol Biol. 2017 Sep;24(9):752-757. [2]. Graf M, et, al. Intracellular Antimicrobial Peptides Targeting the Protein Synthesis Machinery. Adv Exp Med Biol. 2019:1117:73-89. [3]. Knappe D, et, al. Continuous Subcutaneous Delivery of Proline-Rich Antimicrobial Peptide Api137 Provides Superior Efficacy to Intravenous Administration in a Mouse Infection Model. Front Microbiol. 2019 Oct 2:10:2283. |