| Bioactivity | Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect[1][2][3]. | ||||||
| Invitro | Apelin-12 (A12) exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and p38 MAPK signaling pathway in mouse[1].Administration of exogenous A12 reduces arterial blood pressure in anesthetized rats due to activation of endothelial nitric oxide synthase and exerts a positive inotropic action in failing myocardium of rodents[2].Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs[4]. | ||||||
| Name | Apelin-12 | ||||||
| CAS | 229961-08-4 | ||||||
| Shortening | RPRLSHKGPMPF | ||||||
| Formula | C64H103N21O14S | ||||||
| Molar Mass | 1422.70 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Apelin-12
CAS: 229961-08-4 F: C64H103N21O14S W: 1422.70
Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan rec
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