Antitumor agent-77_product_DataBase

Bioactivity	Antitumor agent-77 is an antitumor agent, inhibits cancer cells growth and migration. Antitumor agent-77 triggers ferroptosis by inhibiting GPx-4 and elevating COX2. Antitumor agent-77 also activates intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and hinders Epithelial-mesenchymal transition (EMT) process of cancer cells[1].
Invitro	Antitumor agent-77 (compound 2a) (30 μM; 4 h) exhibits better solubility and improved cellular uptake than Carboplatin (HY-17393) in A549 cells[1].Antitumor agent-77 (20 μM; 36 h) produces cytotoxicity by inducing apoptosis of A549 cancer cells[1].Antitumor agent-77 (20 μM; 24 h) results in significant down-regulation of Bcl-2 and upregulation of Bax, also leads to E-cadherin increase, Vimentin decrease[1]. Antitumor agent-77 (20 μM; 24 h) arrests cell cycle at S phase and G2/M phase[1].Antitumor agent-77 (10 μM; 12 h) inhibits cells migration with inhibition rate of 52%[1]. Apoptosis Analysis[1] Cell Line:
In Vivo	Antitumor agent-77 (compound 2a) (6 μg/kg; i.v.; injected on day 8, 10, 12) exhibits similar potency compared with Oxaliplatin (HY-17371), without significant damage to kidney and liver as well as weight loss[1]. Animal Model:
Name	Antitumor agent-77
Formula	C7H11F3N2O5Pt
Molar Mass	455.25
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Liu F, et al. Design and biological features of platinum (II) complexes with 3-hydroxy-3-(Trifluoromethyl)cyclobutane-1,1-Dicarboxylate as a leaving ligand. Eur J Med Chem. 2022 Nov 15;242:114673.

PeptideDB

Antitumor agent-77

CAS: F: C7H11F3N2O5Pt W: 455.25