Antitumor agent-143_product_DataBase

Bioactivity	Antitumor agent-143 (compound 2c) is an antitumor agent that blocks cell proliferation of A549 cells during the S phase and induces an early apoptosis. Antitumor agent-143 induces cell death via ferroptosis, apoptosis by a ROS-mediated mitochondrial dysfunction pathway and GSDMD-mediated pyroptosis[1].
Invitro	Antitumor agent-143（compound 2c；48h）抑制 A549、B16、HCT116 和 HepG2 细胞的生长，IC50 值分别为 2.2 μM、2.5 μM、2.5 μM 和 1 μM[1] .Antitumor agent-143 (compound 2c) 可阻断 A549 细胞 S 期的细胞增殖并诱导早期细胞凋亡[1]。Antitumor agent-143 (compound 2c) 会导致 ROS 和 Ca2+ 量升高。这导致线粒体膜电位降低、线粒体通透性转换孔开放以及细胞色素 c[1] 增加。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Antitumor agent-143 相关抗体:
In Vivo	Antitumor agent-143 (compound 2c) 减少了小鼠的肿瘤体积[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
Formula	C47H29Cl2F6IrN9P
Molar Mass	1127.88
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Huiyan Hu, et al. Synthesis and mitochondria-localized iridium (III) complexes induce cell death through pyroptosis and ferroptosis pathways. Eur J Med Chem. 2024 Feb 29:268:116295.

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