| Bioactivity | Antisauvagine-30 (aSvg-30) is a potent, competitive and selective CRF2 receptor antagonist with Kd values of 1.4 nM and 153.6 nM for mouse CRF2β and rat CRF1 receptors, respectively[1]. |
| Target | Kd: 1.4 nM (mouse CRF2β);Kd: 153.6 nM (rat CRF1) |
| Name | Antisauvagine-30 |
| CAS | 220673-95-0 |
| Sequence | {D-Phe}-His-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2 |
| Shortening | (D-Phe)-HLLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2 |
| Formula | C161H274N48O46S |
| Molar Mass | 3650.26 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. O Brauns, et al. Pharmacological and chemical properties of astressin, antisauvagine-30 and alpha-helCRF: significance for behavioral experiments. Neuropharmacology. 2001 Sep;41(4):507-16. [2]. Farahnaz Sananbenesi, et al. Mitogen-activated protein kinase signaling in the hippocampus and its modulation by corticotropin-releasing factor receptor 2: a possible link between stress and fear memory. J Neurosci |
Antisauvagine-30
CAS: 220673-95-0 F: C161H274N48O46S W: 3650.26
Antisauvagine-30 (aSvg-30) is a potent, competitive and selective CRF2 receptorantagonist with Kd values of 1.4 nM and 1
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