| Bioactivity | Antioxidant agent-8 is an orally active inhibitor of Aβ1-42 deposition. Antioxidant agent-8 inhibits fibril aggregation (IC50=11.15 µM) and promotes fibril disaggregation (IC50=6.87 µM). Antioxidant agent-8 also inhibits Cu2+-induced Aβ1-42 fibril aggregation (IC50=3.69 µM) and promotes Cu2+-induced Aβ1-42 fibril disaggregation (IC50=3.35 µM). Antioxidant agent-8 has antioxidant activity, anti-inflammatory activity, biosafety, blood-brain barrier permeability and neuroprotective effect[1]. |
| Invitro | Antioxidant agent-8 (compound 30) (50 µM；24 h) 选择性的与 Cu2+、 Fe2+、Zn2+、Fe3+ 和 Al3+ 金属离子螯合，显著抑制自身和 Cu2+ 诱导的 Aβ1-42 原纤维聚集和分解[1]。Antioxidant agent-8 (2.5、5 和 10 µM；24 h) 促进 BV-2 细胞清除 Aβ1-42，减少了 Aβ1-42 诱导的细胞凋亡，以浓度依赖性的方式保护神经[1]。 Western Blot Analysis[1] Cell Line: |
| In Vivo | Antioxidant agent-8 (compound 30) (15 mg/kg；腹腔注射；单剂量) 显示出血脑通透性并在海马体中聚集[1]。Antioxidant agent-8 (2000 mg/kg；腹腔注射；单剂量) 显示出生物安全性[1]。Antioxidant agent-8 (20 mg/kg；口服给药；每天一次，持续 25 天) 显著改善了由东莨菪碱 (HY-N0296) 引起的焦虑、记忆缺陷、认知缺陷[1]。 Animal Model: |
| Name | Antioxidant agent-8 |
| Formula | C13H12O5 |
| Molar Mass | 248.23 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Liu X, et al. Novel neuroprotective pyromeconic acid derivatives with concurrent anti-Aβ deposition, anti-inflammatory, and anti-oxidation properties for treatment of Alzheimer's disease. Eur J Med Chem. 2023 Feb 15;248:115120. |