| Bioactivity | Antimicrobial agent-9 (Compound 16) is an antimicrobial agent with an MIC range of 4-8 μg/mL against gram-positive and gram-negative bacteria. Antimicrobial agent-9 also shows anti-inflammatory activity[1]. |
| Invitro | Antimicrobial agent-9 (Compound 16) (0-256 μg/mL; 18-24 h) shows antibacterial activity with geometric mean (GM) values of the MICs of 4.5 μg/mL[1].Antimicrobial agent-9 shows minimum hemolytic concentration (MHC) of >256 μg/mL, the therapeutic index is 113.8[1].Antimicrobial agent-9 (5 or 20 μg/mL; 18 h) effectively inhibits the release and expression of NO and TNF-α from LPS-stimulated RAW 264.7 cells[1].Antimicrobial agent-9 is resistant to various physiological salts, human serum, and proteases[1].Antimicrobial agent-9 exhibits synergistic antimicrobial activity in combination with three conventional antibiotics (Chloramphenicol (HY-B0239), Ciprofloxacin (HY-B0356), and oxacillin) against MDRPA and MRSA, is promising adjuvants in combination with clinically used antibiotics[1]. Cell Viability Assay[1] Cell Line: |
| Name | Antimicrobial agent-9 |
| Formula | C43H62N16 |
| Molar Mass | 803.06 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Dinesh Kumar S, et al. Cationic, amphipathic small molecules based on a triazine-piperazine-triazine scaffold as a new class of antimicrobial agents. Eur J Med Chem. 2022 Sep 8;243:114747. |