Antifungal agent 41_product_DataBase

Bioactivity	Antifungal agent 41 (compound B01) is an antifungal agent. Antifungal agent 41 shows inhibitory effect on Candida albicans in virto and vivo. Antifungal agent 41 can be used for the research of invasive fungal infections[1].
Invitro	Antifungal agent 41 (0.25-128 μg/mL) shows antifungal activities to C.alb, C.alb (sc5314), C.gla, C.par, C.kru, C.zey, C.neo and A.f with MIC values of 2, 1, 8, 2, 8, 0.25, 4 and 1 μg/mL, respectively[1].Antifungal agent 41 (0-64 μg/mL; 24 h) shows antifungal activities against pathogenic fluconazole-resistant Candida albicans with MIC values of 2, 8, 4, 2 and 4 μg/mL for strain CaR, 17#, 632, 901 and 904, respectively[1].Antifungal agent 41 (0-64 μg/mL; 24 h) shows antifungal activities against Candida albicans with MFC value of 16, 8, 16, >64, 16, 2 and 4 μg/mL for C.alb, C.alb (sc5314), strain CaR, 17#, 632, 901 and 904, respectively[1].Antifungal agent 41 (0-1024 μg/mL; 1.5-24 h) inhibits C.alb ATCC SC5314 and CPCC400616 biofilms with SMIC50s of 0.5 μg/mL and 0.5-4 μg/mL, with SMIC80s of 4-32 μg/mL and 2-4 μg/mL, respectively[1]. Cell Cytotoxicity Assay[1] Cell Line:
In Vivo	Antifungal agent 4 (6-12 mg/kg; i.p. once daily for 5 days) shows in vivo antifungal effects[1]. Animal Model:
Name	Antifungal agent 41
Formula	C22H18Cl4N4Se2
Molar Mass	638.14
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Xu H, et al. Discovery of novel selenium-containing azole derivatives as antifungal agents by exploiting the hydrophobic cleft of CYP51. Eur J Med Chem. 2022 Aug 28;243:114707.

PeptideDB

Antifungal agent 41

CAS: F: C22H18Cl4N4Se2 W: 638.14