Antiflammin-1_product_DataBase

Bioactivity	Antiflammin-1 is an anti-inflammatory peptide 1 (MQMKKVLDS). Antiflammin-1 is a derivative of uteroglobin. Antiflammin-1 has anti-inflammatory and antifibrotic actions in bleomycin (HY-108345)-induced lung injury[1][2][3].
Invitro	Antiflammin-1 (10 μM) 可抑制 TGF-β1 诱导的 NIH3T3 细胞增殖，该增殖由 uteroglobin 受体介导[1]。 0 --> Antiflammin-1 相关抗体:
In Vivo	Antiflammin-1 (2-10 mg/kg，腹腔注射，每天，持续 6 天) 可降低博莱霉素治疗小鼠的 TNF-α 和 IL-1β 水平。 Antiflammin-1 在博来霉素 (HY-108345) 诱导的肺损伤中具有抗炎和抗纤维化作用[1]。
Name	Antiflammin-1
CAS	118850-71-8
Sequence	Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser
Shortening	MQMKKVLDS
Formula	C45H82N12O14S2
Molar Mass	1079.33
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Liu W, et al. Antiflammin-1 attenuates bleomycin-induced pulmonary fibrosis in mice. Respir Res. 2013 Oct 8;14(1):101. [2]. Camussi G, et al. Antiinflammatory peptides (antiflammins) inhibit synthesis of platelet-activating factor, neutrophil aggregation and chemotaxis, and intradermal inflammatory reactions. J Exp Med. 1990 Mar 1;171(3):913-27. [3]. Martínez Leo EE, et al. Biopeptides with antioxidant and anti-inflammatory potential in the prevention and treatment of diabesity disease. Biomed Pharmacother. 2016 Oct;83:816-826.

PeptideDB