Anticancer agent 83_product_DataBase

Bioactivity	Anticancer agent 83 is a potent anticancer agent, inhibits LOX IMVI cells growth with a GI50 value of 0.15 mM. Anticancer agent 83 reduces mitochondrial membrane potential and induces DNA damage to induces leukemia cells apoptosis[1].
Invitro	Anticancer agent 83 (compound 4a) (0.01-100 μM; 24 h) showing strong activity towards human colon carcinoma HCT116 p53−/− cells with deletion of P53 gene (GI50=8.4 μM), human epidermoid cervix carcinoma KB3-1 (GI50=7.4 μM), human ovarian carcinoma Skov 3 cells (GI50=10 μM), and human chronic myelogenous leukemia K562 cells (GI50=5.4 μM)[1].Anticancer agent 83 (0.5 μM; 24 h) interrupts DNA stability and induction of apoptosis in Jurkat cells, and decreases mitochondrial membrane potential[1]. Cell Viability Assay[1] Cell Line:
Name	Anticancer agent 83
CAS	904815-29-8
Formula	C20H19N5OS
Molar Mass	377.46
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Pokhodylo N, et al. Novel N-(4-thiocyanatophenyl)-1H-1,2,3-triazole-4-carboxamides exhibit selective cytotoxic activity at nanomolar doses towards human leukemic T-cells. Eur J Med Chem. 2022 Nov 5;241:114633.

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