| Bioactivity | Anticancer agent 201 (Compound 2f) has IC50 values in the low micromolar range for multiple tumor cell lines. Anticancer agent 201 is highly cytotoxic to CCRF-CEM cells in vitro, inducing apotosis by activating caspase-3 in the intrinsic mitochondrial pathway and lysis of PARP, as well as reducing the expression of Bcl-2 and Bcl-XL proteins. Anticancer agent 201 can be used in cancer research[1]. |
| Invitro | Anticancer agent 201 (Compound 2f) (3.5 μM, 17.5 μM; 24 小时) 能显著地诱导细胞毒性反应、增加凋亡细胞的数量，并导致 CCRF-CEM 细胞的线粒体膜电位呈剂量依赖性降低[1]。Anticancer agent 201 (3.5 μM, 17.5 μM; 24 小时) 在 CCRF-CEM 细胞中阻塞或减慢 G0/G1 期的细胞周期，降低 S 期细胞比例，并能抑制 RNA 的合成[1]。Anticancer agent 201 对 8 种肿瘤 (包括多药耐药变异体) 和 2 种正常成纤维细胞系的细胞毒活性[1]Cell lines |
| Formula | C34H49F3O4 |
| Molar Mass | 578.75 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kazakova A, et al. Novel triterpenoid pyrones, phthalimides and phthalates are selectively cytotoxic in CCRF-CEM cancer cells - Synthesis, potency, and mitochondrial mechanism of action. Eur J Med Chem. 2024;269:116336. |