| Bioactivity | Antibacterial agent 98 (compound g37) is a potent and orally active antibacterial agent. Antibacterial agent 98 inhibits the ATPase activity of Gyrase B and impairs Staphylococcus aureus (S. aureus ) DNA supercoiling. Antibacterial agent 98 shows antibacterial activity and not induce resistance development of MRSA (methicillin-resistant S. aureus)[1]. |
| Invitro | Antibacterial agent 98 (compound g37) shows antibacterial activity with an NICs of 0.1 μg/mL for S. aureus ATCC29213 and an IC50 of 0.15 µM for GyrB[1].Antibacterial agent 98 shows cytotoxicity with IC50s of 55.3, 38.8 µM for HepG2, HUVEC cells, respectively[1]. |
| Name | Antibacterial agent 98 |
| CAS | 2408695-41-8 |
| Formula | C17H13N5O3S2 |
| Molar Mass | 399.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xue W, et al. N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides bearing heteroaromatic rings as novel antibacterial agents: Design, synthesis, biological evaluation and target identification. Eur J Med Chem. 2020 Feb 15;188:112022. |
Antibacterial agent 98
CAS: 2408695-41-8 F: C17H13N5O3S2 W: 399.45
Antibacterial agent 98 (compound g37) is a potent and orally active antibacterial agent. Antibacterial agent 98 inhibits
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