Anti-inflammatory agent 31_product_DataBase

Bioactivity	Anti-inflammatory agent 31 (enone 17) is a kind of andrographolide derivatives, is a anti-inflammatory agent. Anti-inflammatory agent 31 inhibits NF-κB activation by upstream blockade of PI3K/Akt and ERK1/2 MAPK activation. Anti-inflammatory agent 31 shows recovery effective of the intracellular GSH levels and protective effect on liver[1].
Invitro	Anti-inflammatory agent 31 (enone 17) (100, 200, and 400 μM; 24 h) prevents the DNA binding of the activated NF-κB p50 subunit in a dose-dependent manner[1].Anti-inflammatory agent 31 reacts as a quick rate (KGSH=0.076 M-1.h-1) and long half-live (T1/2=6.47 h)[1].Anti-inflammatory agent 31 (5, 20, and 50 μM; 24 h) shows recovery effective of the intracellular GSH levels, and (5 μM) induced more than 2.5-fold increase in GSH levels as compared to the basal levels[1].Anti-inflammatory agent 31 (5, 20, and 50 μM; 24 h) displays low cytotoxicity in LO2 and HEK293 cells with CC50 of 14.68, 26.25 μM, respectively[1]. Immunofluorescence[1] Cell Line:
In Vivo	Anti-inflammatory agent 31 (enone 17) (i.p.; 0.3, 1.0 mg/kg) decreases total white blood cell and neutrophils counts, and alleviates LPS-induced acute lung injury in a dose-dependent manner in mouse[1]. Animal Model:
Name	Anti-inflammatory agent 31
Formula	C19H30O3
Molar Mass	306.44
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Tran QTN, Tan DWS, Wong WSF, Chai CLL. From irreversible to reversible covalent inhibitors: Harnessing the andrographolide scaffold for anti-inflammatory action. Eur J Med Chem. 2020 Oct 15;204:112481.

PeptideDB

Anti-inflammatory agent 31

CAS: F: C19H30O3 W: 306.44