| Bioactivity | Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase[1][2][3][4]. | ||||||||||||
| Invitro | Amentoflavone (1-60 µM) inhibits the production of nitric oxide in a concentration-dependent manner in RAW 264.7 cells[2].Amentoflavone (50-200 µM) inhibits the viability of U-87 MG cells with IC50 value of 100 µM at 48 h[3].Amentoflavone (0, 50, 100 µM; 48 h) induces apoptosis and cell cycle arrest at sub-G1 phase[3].Amentoflavone (0, 50, 100 µM; 48 h) inhibits NF-ĸB activation and decreases the expression of MCL1 and C-FLIP protein in U-87 MG cells[3].Amentoflavone (0-32 µg/ml) shows antibacterial activity with MICs of 8, 4, 32, 8, 16, 8 µg/ml for E. faecium ATCC 19434, S. aureus ATCC 25923, S. mutans ATCC 3065, E. coli O-157 ATCC 25922, E. coli ATCC 43895, P. aeruginosa ATCC 27853, respectively[4]. Cell Viability Assay[3] Cell Line: | ||||||||||||
| Name | Amentoflavone | ||||||||||||
| CAS | 1617-53-4 | ||||||||||||
| Formula | C30H18O10 | ||||||||||||
| Molar Mass | 538.46 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Amentoflavone
CAS: 1617-53-4 F: C30H18O10 W: 538.46
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows
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