Aluminum Hydroxide_product_DataBase

Bioactivity

Aluminum Hydroxide is an orally active main form of aluminum used as adjuvant. Aluminum hydroxide-based adjuvant researches include the repository effect, pro-phagocytic effect, and activation of the pro-inflammatory NLRP3 pathway. Aluminum Hydroxide also acts as adjuvant to compensate low inherent immunogenicity of subunit vaccines[1][2].

In Vivo

Aluminum Hydroxide (orally; 100 mg/kg/day for 7 days) increases lipid peroxidation and decreases the activity of SOD in the brain. Aluminum Hydroxide can dissolve in distilled water to be a homogeneous suspension[3].

Name

Aluminum Hydroxide

CAS

21645-51-2

Formula

AlH3O3

Molar Mass

78.00

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. He P, et al. Advances in aluminum hydroxide-based adjuvant research and its mechanism. Hum Vaccin Immunother. 2015;11(2):477-88. [2]. Amini Y, et al. Aluminum hydroxide nanoparticles show strong activity to stimulate Th-1 immune response against tuberculosis. Artif Cells Nanomed Biotechnol. 2017 Nov;45(7):1331-1335. [3]. Ohtawa M, et al. Effect of aluminum ingestion on lipid peroxidation in rats. Chem Pharm Bull (Tokyo). 1983 Apr;31(4):1415-8.

PeptideDB

Aluminum Hydroxide

CAS: 21645-51-2 F: AlH3O3 W: 78.00