| Bioactivity | Alphadolone acetate (Alfadolone acetate) is a steroid anaesthetic, with antinociception[1]. |
| In Vivo | Alphadolone acetate (anaesthetized with a 3:1 mixture of Alphaxalone and Alphadolone acetate; i.m.) blocks the oestrogen-stimulated luteinizing hormone (LH) surge and impairs pulsatile secretion in female rats, when combined with alphaxalonet[2].Alphadolone acetate (14 mL/kg; i.p.; single dosage) decreases serum concentrations of LH in castrated rats[3]. Animal Model: |
| Name | Alphadolone acetate |
| CAS | 23930-37-2 |
| Formula | C23H34O5 |
| Molar Mass | 390.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nadeson R, et al. Antinociceptive properties of neurosteroids II. Experiments with Saffan and its components alphaxalone and alphadolone to reveal separation of anaesthetic and antinociceptive effects and the involvement of spinal cord GABA(A) receptors. [2]. Dyer RG, Mansfield S. Anaesthesia with alphaxalone plus alphadolone acetate blocks the oestrogen-stimulated LH surge and impairs pulsatile LH secretion in ovariectomized female rats. J Endocrinol. 1984 Jul;102(1):27-31. [3]. Emanuele MA, et al. Anaesthesia with alphaxalone plus alphadolone acetate decreases serum concentrations of LH in castrated rats. J Endocrinol. 1987 Nov;115(2):221-3. |