Allopurinol sodium

CAS: 17795-21-0 F: C5H5N4NaO W: 160.11

Allopurinol sodium is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 µM. Allopurino

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Bioactivity	Allopurinol sodium is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 µM. Allopurinol sodium can be used in the treatment of hyperuricemia and gout. Allopurinol sodium decreases the expression of HIF-1α and HIF-2α protein. Allopurinol sodium shows anti-depressant and anti-nociception activity. Anti-leishmanial effect[1][2][3][4][5].
Invitro	Allopurinol sodium (0, 10, 100, 1000 µg/ml; 17 h) decreases the expression of HIF-1α and HIF-2α protein in HFF and HUVEC cells[5].Allopurinol sodium (0, 10, 100, 1000 µg/ml; 24 h) reduces angiogenesis traits of HUVEC cells[5]. Western Blot Analysis[5] Cell Line:
In Vivo	Allopurinol sodium (39 mg/kg; p.o.; daily for 21 successive days) shows anti-depressant activity in mouse[3].Allopurinol sodium (10-400 mg/kg; i.p.) induces anti-nociception activity in mouse[4]. Animal Model:
Name	Allopurinol sodium
CAS	17795-21-0
Formula	C5H5N4NaO
Molar Mass	160.11
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006;58(1):87-114. [2]. Pfaller MA, et al. Antileishmanial effect of allopurinol. Antimicrob Agents Chemother. 1974;5(5):469-472. [3]. Karve AV, et al. Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice. Indian J Pharmacol. 2013 May-Jun;45(3):244-7. [4]. Schmidt AP, et al. Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors. Br J Pharmacol. 2009 Jan;156(1):163-72. [5]. Sun Y, et al. Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia. PLoS One. 2015 Apr 1;10(4):e0123649.

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