| Bioactivity | Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis[1]. |
| Invitro | Alexidine (10 µM, 24 hours) treatment can decimate the biofilm community[1].Alexidine (0-60 μg/ml, 24 hours) treatment can kill HUVECs and lung A549 cells[1]. Cell Viability Assay[1] Cell Line: |
| In Vivo | Alexidine (Jugular vein-catheterized; 48 hours; 3 µg/ml; once) can decimate preformed biofilms growing in the jugular vein catheters of mice[1]. Animal Model: |
| Name | Alexidine |
| CAS | 22573-93-9 |
| Formula | C26H56N10 |
| Molar Mass | 508.79 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zeinab Mamouei, et al. Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens. mSphere. 2018 Oct 31;3(5):e00539-18. |