Agelastatin A_product_DataBase

Bioactivity	Agelastatin A ((-)-Agelastatin A; AglA), a tetracyclic alkaloid isolated from the sponge Agelas dendromorpha, induces apoptosis and arrests cells in the G2/M phase of the cell cycle, exhibiting antitumor activity[1].
Invitro	Agelastatin A(0-2 μM, 48 h) 作用于 U-937、HeLa、A549、BT549 以及 IMR90 细胞的 IC50值分别是 67 nM, 708 nM, 1.05 μM, 278 nM 和 1.11 μM[1]。 Agelastatin A(0-1 μM, 48 h) 作用于 CEM、Jurkat、Daudi、HL-60 和 CA46 细胞的 IC50值分别是20，74，20，138 和187 nM[1]。 Agelastatin A(0-150 nM, 16 h)可以剂量依赖性的诱导U-937细胞周期停滞在 G2/M 期[1]。
In Vivo	The pharmacokinetic parameters of Agelastatin A(1a) a single 2.5 mg/kg dose in mice[2]. Parameter/td> intravenous (IV)
Name	Agelastatin A
CAS	152406-28-5
Formula	C12H13BrN4O3
Molar Mass	341.16
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Sunkyu Han, et al. Synthesis and anticancer activity of all known (-)-agelastatin alkaloids. J Org Chem. 2013 Dec 6;78(23):11970-84. [2]. E Paige Stout, et al. Potent fluorinated agelastatin analogues for chronic lymphocytic leukemia: design, synthesis, and pharmacokinetic studies. J Med Chem. 2014 Jun 26;57(12):5085-93. doi: 10.1021/jm4016922. Epub 2014 Jun.

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