| Bioactivity | Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells[1][2]. | |||||||||
| Invitro | Aeroplysinin 1 shows anti-proliferative effect against tumor cells (HT-1080, HTC-116, HeLa, THP-1, NOMO-1 and HL-60 cells), with IC50s ranging from 2.3 to 17 μM[1]. Aeroplysinin-1 also exhibits an antiviral activity toward HIV-1 caused by inhibition of its reverse transcriptase activity[1].Aeroplysinin 1 inhibits P. phosphoreum, C. wailesii, P. minimum and HIV with IC50s of 3.5, 5.6, 7.0 and 14.6 μM[1]. Aeroplysinin 1 inhibits human endothelial cells (EVLC-2, HMEC, RF-24, and HUVEC cells), with IC50s ranging from 2.6 to 4.7 μM[2].(+)-Aeroplysinin-1 (0.25-0.5 μM) blocks the EGF-dependent proliferation of both MCF-7 and ZR-75-1 human breast cancer cells and inhibits the ligand-induced endocytosis of the EGF receptor in vitro[3]. | |||||||||
| Name | Aeroplysinin 1 | |||||||||
| CAS | 28656-91-9 | |||||||||
| Formula | C9H9Br2NO3 | |||||||||
| Molar Mass | 338.98 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
|
Aeroplysinin 1
CAS: 28656-91-9 F: C9H9Br2NO3 W: 338.98
Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effect
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.